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But there are several obstacles to the development of this senolytic approach such as the long-term effect of CAR-T cells therapy with possible aspecific toxicity in different organs 56 , the cost and the difficulty during process development 57 or the selection of non-exhausted T cells to generate efficient therapy 58,59

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[DOI] [PMC free article] [PubMed] [Google Scholar] 169.Vukusic D., Zenko Sever A., Sever M., Drmic D., Milavic M., Sikiric S., Rasic D., Krezic I., Gojkovic S., Prtoric A., et al